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Papers of note in Science Translational Medicine 9 (401)

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Sci. Signal.  08 Aug 2017:
Vol. 10, Issue 491, eaao4938
DOI: 10.1126/scisignal.aao4938

This week’s articles describe a way to enhance BH3 mimetics in cancer therapy and a method to achieve targeted delivery of miRNAs to tumors.

CANCER THERAPY

Cutting off another tumor lifeline

Merino et al. report that inhibiting the prosurvival protein MCL-1 enhances the effectiveness of conventional BH3 mimetic therapies in triple-negative and HER2-amplified breast cancer.

Fixing with folate

Orellana et al . developed a nontoxic way to deliver microRNAs directly to tumors in vivo using folate.

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